Therefore, the EGFR-PI3K-PDK1 pathway could activate the YAP signaling, and the activated EGFR signaling could promote the HCC cell growth in a YAP-independent manner. Combined targeting of YAP and EGFR signaling by simvastatin and the EGFR signaling inhibitors, including the EGFR tyrosine kinase inhibitor (TKI) gefitinib, the RAF inhibitor sorafenib and the MEK inhibitor trametinib, presented strong synergistic cytotoxicities in HCC cells. In addition, EGF could promote the proliferation of HCC cells in a YAP-independent manner. While YAP knockdown hardly affected the EGFR signaling. Further studies indicated that EGFR signaling mainly acted through the PI3K-PDK1 (Phosphoinositide 3-kinase-Phosphoinositide-dependent kinase-1) pathway to activate YAP, but not the AKT and MAPK pathways. We found that the activated EGFR signaling could bypass RhoA to promote the expression of YAP(Yes-associated protein), the core effector of the Hippo signaling, and its downstream target Cyr61. However, the crosstalk between these two pathways and its implications in targeted therapy remains unclear. Manga titles: Food Wars! Shokugeki no Sanji One Piece Īnime titles: ARASHI: A-RA-SHI : Reborn Hungry Days x Bump of Chicken: Kinen Satsuei Hungry Days x One Piece Kyuutai Panic Adventure Returns! Look Plus x One Piece CM Nissan Serena x One Piece 3D: Mugiwara Chase One Piece One Piece 3D2Y: Overcoming Ace's Death! Luffy's Pledge to His Friends! One Piece 3D: Mugiwara Chase One Piece: Adventure of Nebulandia One Piece: Annecy Festival 60th Anniversary One Piece: Django's Dance Carnival One Piece: Dream Soccer King! One Piece: Episode of East Blue One Piece: Episode of Luffy - Hand Island no Bouken One Piece: Episode of Merry - Mou Hitori no Nakama no Monogatari One Piece: Episode of Nami - Koukaishi no Namida to Nakama no Kizuna One Piece: Episode of Sabo One Piece: Episode of Skypiea One Piece Film: Gold One Piece Film: Gold - Cine Mike Popcorn Kokuchi One Piece Film: Gold ~Episode 0~ 711 ver.The epidermal growth factor receptor (EGFR) pathway and Hippo signaling play an important role in the carcinogenesis of hepatocellular carcinoma (HCC). Manga titles: Food Wars! Shokugeki no Sanji One Piece One Piece: Roronoa Zoro Falls Into the Sea One Piece: Strong World Īnime titles: Hungry Days x Bump of Chicken: Kinen Satsuei One Piece Manga titles: Cross Epoch Food Wars! Shokugeki no Sanji One Piece One Piece Gakuen One Piece Party One Piece: Roronoa Zoro Falls Into the Sea One Piece x Toriko: Jisshoku! Akuma no Mi!! Īnime titles: Hungry Days x Bump of Chicken: Kinen Satsuei One Piece One Piece: Episode of East Blue One Piece: Episode of Merry - Mou Hitori no Nakama no Monogatari One Piece: Strong World - Episode 0 One Piece Film: Z One Piece: Kinkyuu Kikaku One Piece Kanzen Kouryakuhou One Piece Movie 10: Strong World One Piece Movie 14: Stampede The meaning of the name SanjiĪnime titles: ARASHI: A-RA-SHI : Reborn Fanta x One Piece Hungry Days x Bump of Chicken: Kinen Satsuei Hungry Days x One Piece Look Plus x One Piece CM Nissan Serena x One Piece 3D: Mugiwara Chase One Piece One Piece 3D2Y: Overcoming Ace's Death! Luffy's Pledge to His Friends! One Piece 3D: Mugiwara Chase One Piece: Adventure of Nebulandia One Piece: Annecy Festival 60th Anniversary One Piece: Django's Dance Carnival One Piece: Dream Soccer King! One Piece: Episode of East Blue One Piece: Episode of Luffy - Hand Island no Bouken One Piece: Episode of Merry - Mou Hitori no Nakama no Monogatari One Piece: Episode of Nami - Koukaishi no Namida to Nakama no Kizuna One Piece: Episode of Sabo One Piece: Episode of Skypiea One Piece Film: Gold One Piece Film: Gold ~Episode 0~ 711 ver. ![]() ![]() ![]() As a Vietnamese name, it is derived from Sino-Vietnamese 蘭 meaning "orchid". Other Chinese characters can form this name as well. Lan ♂ From Chinese 兰 (lán) meaning "orchid, elegant" (which is usually only feminine) or 岚 (lán) meaning "mountain mist". Xia ♂ 夏, 霞 From Chinese 夏 (xià) meaning "summer, great, grand", 霞 (xiá) meaning "rosy clouds", or other characters that are pronounced similarly.Īnime titles: MegaMan: NT Warrior Rockman EXE Axess Rockman.EXE Beast Rockman.EXE Beast+ Rockman.EXE: Hikari to Yami no Program Rockman.EXE Stream Anime titles: Full Metal Panic! The Second Raid Full Metal Panic! The Second Raid: Episode 00
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